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December 15, 2020; vol. 117 no. 50

This Week in PNAS

This week's research highlights

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In This Issue
PNAS December 15, 2020 117 (50) 31555-31557; https://doi.org/10.1073/iti5020117
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Inner Workings

An over-the-shoulder look at scientists at work

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Inner Workings: Early Mars may have boasted a large ocean and cool climate
Front Matter
Nola Taylor Redd

PNAS December 15, 2020 117 (50) 31558-31560; first published December 2, 2020. https://doi.org/10.1073/pnas.2022986117
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QnAs

Interviews with leading scientific researchers and newsmakers

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QnAs with Juan Carrillo
Beth Azar

PNAS December 15, 2020 117 (50) 31561-31562; first published November 23, 2020. https://doi.org/10.1073/pnas.2022915117

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Profile

The life and work of NAS members

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Profile of Sandra L. Schmid
Jennifer Viegas

PNAS December 15, 2020 117 (50) 31563-31566; first published November 30, 2020. https://doi.org/10.1073/pnas.2022997117

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Functional characterization of 67 endocytic accessory proteins using multiparametric quantitative analysis of CCP dynamics
- Nov 30, 2020
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Commentaries

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Hundreds of thousands of cell generations reveal a treasure chest of genome alterations
Juan Lucas Argueso and Eric Alani

PNAS December 15, 2020 117 (50) 31567-31569; first published November 16, 2020. https://doi.org/10.1073/pnas.2021185117

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Genome-wide mapping of spontaneous genetic alterations in diploid yeast cells
- Oct 26, 2020
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HLA polymorphism and tapasin independence influence outcomes of HIV and dengue virus infection
Tiziana Di Pucchio and Rafick-Pierre Sekaly

PNAS December 15, 2020 117 (50) 31570-31572; first published November 25, 2020. https://doi.org/10.1073/pnas.2020109117

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HLA tapasin independence: broader peptide repertoire and HIV control
- Oct 23, 2020
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Straightening up for life in a biofilm
Heidi A. Arjes and Kerwyn Casey Huang

PNAS December 15, 2020 117 (50) 31573-31574; first published November 17, 2020. https://doi.org/10.1073/pnas.2021127117

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Vibrio cholerae adapts to sessile and motile lifestyles by cyclic di-GMP regulation of cell shape
- Nov 02, 2020
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Letters

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Bisexual orientation cannot be reduced to arousal patterns
Brian A. Feinstein and M. Paz Galupo

PNAS December 15, 2020 117 (50) 31575-31576; first published November 17, 2020. https://doi.org/10.1073/pnas.2016612117

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Bisexuality in men exists but cannot be decoded from men’s genital arousal
- Nov 17, 2020
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Bisexuality in men exists but cannot be decoded from men’s genital arousal
Alon Zivony

PNAS December 15, 2020 117 (50) 31577-31578; first published November 17, 2020. https://doi.org/10.1073/pnas.2016533117

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Bisexual orientation cannot be reduced to arousal patterns
- Nov 17, 2020
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Reply to Feinstein and Galupo and to Zivony: Sexual arousal pattern is an objective although imperfect window on sexual orientation
J. Michael Bailey

PNAS December 15, 2020 117 (50) 31579; first published November 17, 2020. https://doi.org/10.1073/pnas.2018065117

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Robust evidence for bisexual orientation among men
- Jul 20, 2020
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Feature frequency profile-based phylogenies are inaccurate
Yuanning Li, Kyle T. David, Xing-Xing Shen, Jacob L. Steenwyk, Kenneth M. Halanych, and Antonis Rokas

PNAS December 15, 2020 117 (50) 31580-31581; first published November 24, 2020. https://doi.org/10.1073/pnas.2013143117

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Reply to Li et al.: Organism tree of life: Gene phylogeny vs. whole-proteome phylogeny
JaeJin Choi and Sung-Hou Kim

PNAS December 15, 2020 117 (50) 31582; first published November 24, 2020. https://doi.org/10.1073/pnas.2015631117

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Whole-proteome tree of life suggests a deep burst of organism diversity
- Feb 04, 2020
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Physical Sciences

Applied Mathematics
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  Event-specific interventions to minimize COVID-19 transmission
  Paul Tupper, Himani Boury, Madi Yerlanov, and Caroline Colijn
  
  PNAS December 15, 2020 117 (50) 32038-32045; first published November 19, 2020. https://doi.org/10.1073/pnas.2019324117
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Biophysics and Computational Biology
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  Vibration enhanced cell growth induced by surface acoustic waves as in vitro wound-healing model
  Manuel S. Brugger, Kathrin Baumgartner, Sophie C. F. Mauritz, Stefan C. Gerlach, Florian Röder, Christine Schlosser, Regina Fluhrer, Achim Wixforth, and Christoph Westerhausen
  
  PNAS December 15, 2020 117 (50) 31603-31613; first published November 30, 2020. https://doi.org/10.1073/pnas.2005203117
  
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  Nonequilibrium models of optimal enhancer function
  Rok Grah, Benjamin Zoller, and Gašper Tkačik
  
  PNAS December 15, 2020 117 (50) 31614-31622; first published December 2, 2020. https://doi.org/10.1073/pnas.2006731117
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  Pattern-induced local symmetry breaking in active-matter systems
  
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  Jonas Denk and Erwin Frey
  
  PNAS December 15, 2020 117 (50) 31623-31630; first published November 30, 2020. https://doi.org/10.1073/pnas.2010302117
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  Individual variations lead to universal and cross-species patterns of social behavior
  
  From the Cover
  
  Sang Hyun Choi, Vikyath D. Rao, Tim Gernat, Adam R. Hamilton, Gene E. Robinson, and Nigel Goldenfeld
  
  PNAS December 15, 2020 117 (50) 31754-31759; first published November 30, 2020. https://doi.org/10.1073/pnas.2002013117
  
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  A complete rule set for designing symmetry combination materials from protein molecules
  Joshua Laniado and Todd O. Yeates
  
  PNAS December 15, 2020 117 (50) 31817-31823; first published November 25, 2020. https://doi.org/10.1073/pnas.2015183117
  
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Chemistry
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  Atomic-scale evidence for highly selective electrocatalytic N−N coupling on metallic MoS₂
  Daoping He, Hideshi Ooka, Yujeong Kim, Yamei Li, Fangming Jin, Sun Hee Kim, and Ryuhei Nakamura
  
  PNAS December 15, 2020 117 (50) 31631-31638; first published November 30, 2020. https://doi.org/10.1073/pnas.2008429117
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  Hierarchical supramolecular assembly of a single peptoid polymer into a planar nanobrush with two distinct molecular packing motifs
  Jing Sun, Zhiwei Wang, Chenhui Zhu, Meiyao Wang, Zhekun Shi, Yuhan Wei, Xiaohui Fu, Xuesi Chen, and Ronald N. Zuckermann
  
  PNAS December 15, 2020 117 (50) 31639-31647; first published December 1, 2020. https://doi.org/10.1073/pnas.2011816117
  
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Computer Sciences
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  The potential harms of the Tor anonymity network cluster disproportionately in free countries
  Eric Jardine, Andrew M. Lindner, and Gareth Owenson
  
  PNAS December 15, 2020 117 (50) 31716-31721; first published November 30, 2020. https://doi.org/10.1073/pnas.2011893117
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Earth, Atmospheric, and Planetary Sciences
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  Enhanced trace element mobilization by Earth’s ice sheets
  Jon R. Hawkings, Mark L. Skidmore, Jemma L. Wadham, John C. Priscu, Peter L. Morton, Jade E. Hatton, Christopher B. Gardner, Tyler J. Kohler, Marek Stibal, Elizabeth A. Bagshaw, August Steigmeyer, Joel Barker, John E. Dore, W. Berry Lyons, Martyn Tranter, Robert G. M. Spencer, and the SALSA Science Team
  
  PNAS December 15, 2020 117 (50) 31648-31659; first published November 23, 2020. https://doi.org/10.1073/pnas.2014378117
  
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  Crustal fingering facilitates free-gas methane migration through the hydrate stability zone
  
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  Xiaojing Fu, Joaquin Jimenez-Martinez, Thanh Phong Nguyen, J. William Carey, Hari Viswanathan, Luis Cueto-Felgueroso, and Ruben Juanes
  
  PNAS December 15, 2020 117 (50) 31660-31664; first published November 30, 2020. https://doi.org/10.1073/pnas.2011064117
  
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Engineering
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  Fingerprint ridges allow primates to regulate grip
  Seoung-Mok Yum, In-Keun Baek, Dongpyo Hong, Juhan Kim, Kyunghoon Jung, Seontae Kim, Kihoon Eom, Jeongmin Jang, Seonmyeong Kim, Matlabjon Sattorov, Min-Geol Lee, Sungwan Kim, Michael J. Adams, and Gun-Sik Park
  
  PNAS December 15, 2020 117 (50) 31665-31673; first published November 30, 2020. https://doi.org/10.1073/pnas.2001055117
  
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  A wireless, skin-interfaced biosensor for cerebral hemodynamic monitoring in pediatric care
  Alina Y. Rwei, Wei Lu, Changsheng Wu, Kelia Human, Emily Suen, Daniel Franklin, Monica Fabiani, Gabriele Gratton, Zhaoqian Xie, Yujun Deng, Sung Soo Kwak, Lizhu Li, Carol Gu, Alanna Liu, Casey M. Rand, Tracey M. Stewart, Yonggang Huang, Debra E. Weese-Mayer, and John A. Rogers
  
  PNAS December 15, 2020 117 (50) 31674-31684; first published November 30, 2020. https://doi.org/10.1073/pnas.2019786117
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  Fuel and oxygen harvesting from Martian regolithic brine
  
  From the Cover
  
  Pralay Gayen, Shrihari Sankarasubramanian, and Vijay K. Ramani
  
  PNAS December 15, 2020 117 (50) 31685-31689; first published November 30, 2020. https://doi.org/10.1073/pnas.2008613117
  
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  Fouling-resistant zwitterionic polymers for complete prevention of postoperative adhesion
  Ershuai Zhang, Boyi Song, Yuanjie Shi, Hui Zhu, Xiangfei Han, Hong Du, Chengbiao Yang, and Zhiqiang Cao
  
  PNAS December 15, 2020 117 (50) 32046-32055; first published November 30, 2020. https://doi.org/10.1073/pnas.2012491117
  
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Physics
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  Periodic training of creeping solids
  
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  Daniel Hexner, Andrea J. Liu, and Sidney R. Nagel
  
  PNAS December 15, 2020 117 (50) 31690-31695; first published November 30, 2020. https://doi.org/10.1073/pnas.1922847117
  
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Sustainability Science
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  Planning universal accessibility to public health care in sub-Saharan Africa
  Giacomo Falchetta, Ahmed T. Hammad, and Soheil Shayegh
  
  PNAS December 15, 2020 117 (50) 31760-31769; first published November 30, 2020. https://doi.org/10.1073/pnas.2009172117
  
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Biological Sciences

Applied Biological Sciences
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  Radiation with reticulation marks the origin of a major malaria vector
  
  Inaugural Article
  
  Scott T. Small, Frédéric Labbé, Neil F. Lobo, Lizette L. Koekemoer, Chadwick H. Sikaala, Daniel E. Neafsey, Matthew W. Hahn, Michael C. Fontaine, and Nora J. Besansky
  
  PNAS December 15, 2020 117 (50) 31583-31590; first published December 1, 2020. https://doi.org/10.1073/pnas.2018142117
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  An engineered 4-1BBL fusion protein with “activity on demand”
  Jacqueline Mock, Marco Stringhini, Alessandra Villa, Michael Weller, Tobias Weiss, and Dario Neri
  
  PNAS December 15, 2020 117 (50) 31780-31788; first published November 25, 2020. https://doi.org/10.1073/pnas.2013615117
  
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  Transforming yeast peroxisomes into microfactories for the efficient production of high-value isoprenoids
  Simon Dusséaux, William Thomas Wajn, Yixuan Liu, Codruta Ignea, and Sotirios C. Kampranis
  
  PNAS December 15, 2020 117 (50) 31789-31799; first published December 2, 2020. https://doi.org/10.1073/pnas.2013968117
  
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Biochemistry
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  FGF23 contains two distinct high-affinity binding sites enabling bivalent interactions with α-Klotho
  Yoshihisa Suzuki, Ekaterina Kuzina, Seong J. An, Francisco Tome, Jyotidarsini Mohanty, Wenxue Li, Sangwon Lee, Yansheng Liu, Irit Lax, and Joseph Schlessinger
  
  PNAS December 15, 2020 117 (50) 31800-31807; first published November 30, 2020. https://doi.org/10.1073/pnas.2018554117
  
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  Refined measurement of SecA-driven protein secretion reveals that translocation is indirectly coupled to ATP turnover
  William J. Allen, Daniel W. Watkins, Mark S. Dillingham, and Ian Collinson
  
  PNAS December 15, 2020 117 (50) 31808-31816; first published November 30, 2020. https://doi.org/10.1073/pnas.2010906117
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Biophysics and Computational Biology
- Open Access
  Nonequilibrium models of optimal enhancer function
  Rok Grah, Benjamin Zoller, and Gašper Tkačik
  
  PNAS December 15, 2020 117 (50) 31614-31622; first published December 2, 2020. https://doi.org/10.1073/pnas.2006731117
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  Fingerprint ridges allow primates to regulate grip
  
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  Seoung-Mok Yum, In-Keun Baek, Dongpyo Hong, Juhan Kim, Kyunghoon Jung, Seontae Kim, Kihoon Eom, Jeongmin Jang, Seonmyeong Kim, Matlabjon Sattorov, Min-Geol Lee, Sungwan Kim, Michael J. Adams, and Gun-Sik Park
  
  PNAS December 15, 2020 117 (50) 31665-31673; first published November 30, 2020. https://doi.org/10.1073/pnas.2001055117
  
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  A complete rule set for designing symmetry combination materials from protein molecules
  Joshua Laniado and Todd O. Yeates
  
  PNAS December 15, 2020 117 (50) 31817-31823; first published November 25, 2020. https://doi.org/10.1073/pnas.2015183117
  
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  Viewing rare conformations of the β₂ adrenergic receptor with pressure-resolved DEER spectroscopy
  Michael T. Lerch, Rachel A. Matt, Matthieu Masureel, Matthias Elgeti, Kaavya Krishna Kumar, Daniel Hilger, Bryon Foys, Brian K. Kobilka, and Wayne L. Hubbell
  
  PNAS December 15, 2020 117 (50) 31824-31831; first published November 30, 2020. https://doi.org/10.1073/pnas.2013904117
  
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  Micellar TIA1 with folded RNA binding domains as a model for reversible stress granule formation
  Keith J. Fritzsching, Yizhuo Yang, Emily M. Pogue, Joseph B. Rayman, Eric R. Kandel, and Ann E. McDermott
  
  PNAS December 15, 2020 117 (50) 31832-31837; first published November 30, 2020. https://doi.org/10.1073/pnas.2007423117
  
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  A hybrid approach reveals the allosteric regulation of GTP cyclohydrolase I
  Rebecca Ebenhoch, Simone Prinz, Susann Kaltwasser, Deryck J. Mills, Robert Meinecke, Martin Rübbelke, Dirk Reinert, Margit Bauer, Lisa Weixler, Markus Zeeb, Janet Vonck, and Herbert Nar
  
  PNAS December 15, 2020 117 (50) 31838-31849; first published November 23, 2020. https://doi.org/10.1073/pnas.2013473117
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  An angular motion of a conserved four-helix bundle facilitates alternating access transport in the TtNapA and EcNhaA transporters
  
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  Gal Masrati, Ramakanta Mondal, Abraham Rimon, Amit Kessel, Etana Padan, Erik Lindahl, and Nir Ben-Tal
  
  PNAS December 15, 2020 117 (50) 31850-31860; first published November 30, 2020. https://doi.org/10.1073/pnas.2002710117
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  Driving integrative structural modeling with serial capture affinity purification
  
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  Xingyu Liu, Ying Zhang, Zhihui Wen, Yan Hao, Charles A. S. Banks, Jeffrey J. Lange, Brian D. Slaughter, Jay R. Unruh, Laurence Florens, Susan M. Abmayr, Jerry L. Workman, and Michael P. Washburn
  
  PNAS December 15, 2020 117 (50) 31861-31870; first published November 30, 2020. https://doi.org/10.1073/pnas.2007931117
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  TAT-RasGAP_317-326 kills cells by targeting inner-leaflet–enriched phospholipids
  Marc Serulla, Gabriel Ichim, Filip Stojceski, Gianvito Grasso, Sergii Afonin, Mathieu Heulot, Tim Schober, Robyn Roth, Cédric Godefroy, Pierre-Emmanuel Milhiet, Kushal Das, Ana J. García-Sáez, Andrea Danani, and Christian Widmann
  
  PNAS December 15, 2020 117 (50) 31871-31881; first published November 30, 2020. https://doi.org/10.1073/pnas.2014108117
  
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  Regulatory mechanisms of tau protein fibrillation under the conditions of liquid–liquid phase separation
  Solomiia Boyko, Krystyna Surewicz, and Witold K. Surewicz
  
  PNAS December 15, 2020 117 (50) 31882-31890; first published December 1, 2020. https://doi.org/10.1073/pnas.2012460117
  
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Cell Biology
- Open Access
  Functional characterization of 67 endocytic accessory proteins using multiparametric quantitative analysis of CCP dynamics
  
  Inaugural Article
  
  Madhura Bhave, Rosa E. Mino, Xinxin Wang, Jeon Lee, Heather M. Grossman, Ashley M. Lakoduk, Gaudenz Danuser, Sandra L. Schmid, and Marcel Mettlen
  
  PNAS December 15, 2020 117 (50) 31591-31602; first published November 30, 2020. https://doi.org/10.1073/pnas.2020346117
  
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  Profile of Sandra L. Schmid
  - Nov 30, 2020
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  Vibration enhanced cell growth induced by surface acoustic waves as in vitro wound-healing model
  
  Video
  
  Manuel S. Brugger, Kathrin Baumgartner, Sophie C. F. Mauritz, Stefan C. Gerlach, Florian Röder, Christine Schlosser, Regina Fluhrer, Achim Wixforth, and Christoph Westerhausen
  
  PNAS December 15, 2020 117 (50) 31603-31613; first published November 30, 2020. https://doi.org/10.1073/pnas.2005203117
  
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  HSATII RNA is induced via a noncanonical ATM-regulated DNA damage response pathway and promotes tumor cell proliferation and movement
  Maciej T. Nogalski and Thomas Shenk
  
  PNAS December 15, 2020 117 (50) 31891-31901; first published November 30, 2020. https://doi.org/10.1073/pnas.2017734117
  
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  Cellular proteostasis decline in human senescence
  Niv Sabath, Flonia Levy-Adam, Amal Younis, Kinneret Rozales, Anatoly Meller, Shani Hadar, Sharon Soueid-Baumgarten, and Reut Shalgi
  
  PNAS December 15, 2020 117 (50) 31902-31913; first published November 30, 2020. https://doi.org/10.1073/pnas.2018138117
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  Scaffold association factor B (SAFB) is required for expression of prenyltransferases and RAS membrane association
  Mo Zhou, Leena Kuruvilla, Xiarong Shi, Stephen Viviano, Ian M. Ahearn, Caroline R. Amendola, Wenjuan Su, Sana Badri, James Mahaffey, Nicole Fehrenbacher, Jane Skok, Joseph Schlessinger, Benjamin E. Turk, David A. Calderwood, and Mark R. Philips
  
  PNAS December 15, 2020 117 (50) 31914-31922; first published November 30, 2020. https://doi.org/10.1073/pnas.2005712117
  
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  Polyphosphate is an extracellular signal that can facilitate bacterial survival in eukaryotic cells
  
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  Ramesh Rijal, Louis A. Cadena, Morgan R. Smith, Joseph F. Carr, and Richard H. Gomer
  
  PNAS December 15, 2020 117 (50) 31923-31934; first published December 2, 2020. https://doi.org/10.1073/pnas.2012009117
  
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Developmental Biology
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  Control of Drosophila wing size by morphogen range and hormonal gating
  Joseph Parker and Gary Struhl
  
  PNAS December 15, 2020 117 (50) 31935-31944; first published November 30, 2020. https://doi.org/10.1073/pnas.2018196117
  
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  Prdm16 is a critical regulator of adult long-term hematopoietic stem cell quiescence
  Kristbjorn O. Gudmundsson, Nhu Nguyen, Kevin Oakley, Yufen Han, Bjorg Gudmundsdottir, Pentao Liu, Lino Tessarollo, Nancy A. Jenkins, Neal G. Copeland, and Yang Du
  
  PNAS December 15, 2020 117 (50) 31945-31953; first published December 2, 2020. https://doi.org/10.1073/pnas.2017626117
  
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Ecology
- Open Access
  Distemper, extinction, and vaccination of the Amur tiger
  
  From the Cover
  
  Martin Gilbert, Nadezhda Sulikhan, Olga Uphyrkina, Mikhail Goncharuk, Linda Kerley, Enrique Hernandez Castro, Richard Reeve, Tracie Seimon, Denise McAloose, Ivan V. Seryodkin, Sergey V. Naidenko, Christopher A. Davis, Gavin S. Wilkie, Sreenu B. Vattipally, Walt E. Adamson, Chris Hinds, Emma C. Thomson, Brian J. Willett, Margaret J. Hosie, Nicola Logan, Michael McDonald, Robert J. Ossiboff, Elena I. Shevtsova, Stepan Belyakin, Anna A. Yurlova, Steven A. Osofsky, Dale G. Miquelle, Louise Matthews, and Sarah Cleaveland
  
  PNAS December 15, 2020 117 (50) 31954-31962; first published November 23, 2020. https://doi.org/10.1073/pnas.2000153117
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  Oxygen limitation may affect the temperature and size dependence of metabolism in aquatic ectotherms
  Juan G. Rubalcaba, Wilco C. E. P. Verberk, A. Jan Hendriks, Bart Saris, and H. Arthur Woods
  
  PNAS December 15, 2020 117 (50) 31963-31968; first published November 30, 2020. https://doi.org/10.1073/pnas.2003292117
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Evolution
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  Fluctuating optimum and temporally variable selection on breeding date in birds and mammals
  Pierre de Villemereuil, Anne Charmantier, Debora Arlt, Pierre Bize, Patricia Brekke, Lyanne Brouwer, Andrew Cockburn, Steeve D. Côté, F. Stephen Dobson, Simon R. Evans, Marco Festa-Bianchet, Marlène Gamelon, Sandra Hamel, Johann Hegelbach, Kurt Jerstad, Bart Kempenaers, Loeske E. B. Kruuk, Jouko Kumpula, Thomas Kvalnes, Andrew G. McAdam, S. Eryn McFarlane, Michael B. Morrissey, Tomas Pärt, Josephine M. Pemberton, Anna Qvarnström, Ole Wiggo Røstad, Julia Schroeder, Juan Carlos Senar, Ben C. Sheldon, Martijn van de Pol, Marcel E. Visser, Nathaniel T. Wheelwright, Jarle Tufto, and Luis-Miguel Chevin
  
  PNAS December 15, 2020 117 (50) 31969-31978; first published November 30, 2020. https://doi.org/10.1073/pnas.2009003117
  
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  Multiple origins of obligate nematode and insect symbionts by a clade of bacteria closely related to plant pathogens
  Vincent G. Martinson, Ryan M. R. Gawryluk, Brent E. Gowen, Caitlin I. Curtis, John Jaenike, and Steve J. Perlman
  
  PNAS December 15, 2020 117 (50) 31979-31986; first published November 30, 2020. https://doi.org/10.1073/pnas.2000860117
  
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  Genome analyses reveal the hybrid origin of the staple crop white Guinea yam (Dioscorea rotundata)
  Yu Sugihara, Kwabena Darkwa, Hiroki Yaegashi, Satoshi Natsume, Motoki Shimizu, Akira Abe, Akiko Hirabuchi, Kazue Ito, Kaori Oikawa, Muluneh Tamiru-Oli, Atsushi Ohta, Ryo Matsumoto, Paterne Agre, David De Koeyer, Babil Pachakkil, Shinsuke Yamanaka, Satoru Muranaka, Hiroko Takagi, Ben White, Robert Asiedu, Hideki Innan, Asrat Asfaw, Patrick Adebola, and Ryohei Terauchi
  
  PNAS December 15, 2020 117 (50) 31987-31992; first published December 2, 2020. https://doi.org/10.1073/pnas.2015830117
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Genetics
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  Targeting progesterone signaling prevents metastatic ovarian cancer
  Olga Kim, Eun Young Park, Sun Young Kwon, Sojin Shin, Robert E. Emerson, Yong-Hyun Shin, Francesco J. DeMayo, John P. Lydon, Donna M. Coffey, Shannon M. Hawkins, Lawrence A. Quilliam, Dong-Joo Cheon, Facundo M. Fernández, Kenneth P. Nephew, Adam R. Karpf, Martin Widschwendter, Anil K. Sood, Robert C. Bast Jr, Andrew K. Godwin, Kathy D. Miller, Chi-Heum Cho, and Jaeyeon Kim
  
  PNAS December 15, 2020 117 (50) 31993-32004; first published December 1, 2020. https://doi.org/10.1073/pnas.2013595117
  
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Immunology and Inflammation
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  Targeting a scavenger receptor on tumor-associated macrophages activates tumor cell killing by natural killer cells
  
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  Silke Eisinger, Dhifaf Sarhan, Vanessa F. Boura, Itziar Ibarlucea-Benitez, Sofia Tyystjärvi, Ganna Oliynyk, Marie Arsenian-Henriksson, David Lane, Stina L. Wikström, Rolf Kiessling, Tommaso Virgilio, Santiago F. Gonzalez, Dagmara Kaczynska, Shigeaki Kanatani, Evangelia Daskalaki, Craig E. Wheelock, Saikiran Sedimbi, Benedict J. Chambers, Jeffrey V. Ravetch, and Mikael C. I. Karlsson
  
  PNAS December 15, 2020 117 (50) 32005-32016; first published November 23, 2020. https://doi.org/10.1073/pnas.2015343117
  
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  Tolerogenic nanoparticles suppress central nervous system inflammation
  Jessica E. Kenison, Aditi Jhaveri, Zhaorong Li, Nikita Khadse, Emily Tjon, Sara Tezza, Dominika Nowakowska, Agustin Plasencia, Vincent P. Stanton Jr, David H. Sherr, and Francisco J. Quintana
  
  PNAS December 15, 2020 117 (50) 32017-32028; first published November 25, 2020. https://doi.org/10.1073/pnas.2016451117
  
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  A thermogenic fat-epithelium cell axis regulates intestinal disease tolerance
  Kevin Man, Christopher Bowman, Kristina N. Braverman, Veronica Escalante, Yuan Tian, Jordan E. Bisanz, Kirthana Ganeshan, Biao Wang, Andrew Patterson, James R. Bayrer, Peter J. Turnbaugh, and Ajay Chawla
  
  PNAS December 15, 2020 117 (50) 32029-32037; first published November 30, 2020. https://doi.org/10.1073/pnas.2012003117
  
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Medical Sciences
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  Event-specific interventions to minimize COVID-19 transmission
  Paul Tupper, Himani Boury, Madi Yerlanov, and Caroline Colijn
  
  PNAS December 15, 2020 117 (50) 32038-32045; first published November 19, 2020. https://doi.org/10.1073/pnas.2019324117
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  Fouling-resistant zwitterionic polymers for complete prevention of postoperative adhesion
  Ershuai Zhang, Boyi Song, Yuanjie Shi, Hui Zhu, Xiangfei Han, Hong Du, Chengbiao Yang, and Zhiqiang Cao
  
  PNAS December 15, 2020 117 (50) 32046-32055; first published November 30, 2020. https://doi.org/10.1073/pnas.2012491117
  
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  Mitochondrial Nuclear Retrograde Regulator 1 (MNRR1) rescues the cellular phenotype of MELAS by inducing homeostatic mechanisms
  Siddhesh Aras, Neeraja Purandare, Stephanie Gladyck, Mallika Somayajulu-Nitu, Kezhong Zhang, Douglas C. Wallace, and Lawrence I. Grossman
  
  PNAS December 15, 2020 117 (50) 32056-32065; first published November 30, 2020. https://doi.org/10.1073/pnas.2005877117
  
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Microbiology
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  Autologous IgG antibodies block outgrowth of a substantial but variable fraction of viruses in the latent reservoir for HIV-1
  Lynn N. Bertagnolli, Joseph Varriale, Sarah Sweet, Jacqueline Brockhurst, Francesco R. Simonetti, Jennifer White, Subul Beg, Kenneth Lynn, Karam Mounzer, Ian Frank, Pablo Tebas, Katharine J. Bar, Luis J. Montaner, Robert F. Siliciano, and Janet D. Siliciano
  
  PNAS December 15, 2020 117 (50) 32066-32077; first published November 25, 2020. https://doi.org/10.1073/pnas.2020617117
  
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  Human sapovirus propagation in human cell lines supplemented with bile acids
  Hirotaka Takagi, Tomoichiro Oka, Takashi Shimoike, Hiroyuki Saito, Takayuki Kobayashi, Tomoko Takahashi, Chika Tatsumi, Michiyo Kataoka, Qiuhong Wang, Linda J. Saif, and Mamoru Noda
  
  PNAS December 15, 2020 117 (50) 32078-32085; first published November 30, 2020. https://doi.org/10.1073/pnas.2007310117
  
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  A bacterial cytolinker couples positioning of magnetic organelles to cell shape control
  
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  Daniel Pfeiffer, Mauricio Toro-Nahuelpan, Ram Prasad Awal, Frank-Dietrich Müller, Marc Bramkamp, Jürgen M. Plitzko, and Dirk Schüler
  
  PNAS December 15, 2020 117 (50) 32086-32097; first published November 30, 2020. https://doi.org/10.1073/pnas.2014659117
  
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  Structure of the Plasmodium-interspersed repeat proteins of the malaria parasite
  Thomas E. Harrison, Adam J. Reid, Deirdre Cunningham, Jean Langhorne, and Matthew K. Higgins
  
  PNAS December 15, 2020 117 (50) 32098-32104; first published November 30, 2020. https://doi.org/10.1073/pnas.2016775117
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  Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion
  Ruochen Zang, James Brett Case, Eylan Yutuc, Xiucui Ma, Sheng Shen, Maria Florencia Gomez Castro, Zhuoming Liu, Qiru Zeng, Haiyan Zhao, Juhee Son, Paul W. Rothlauf, Alex J. B. Kreutzberger, Gaopeng Hou, Hu Zhang, Sayantan Bose, Xin Wang, Michael D. Vahey, Kartik Mani, William J. Griffiths, Tom Kirchhausen, Daved H. Fremont, Haitao Guo, Abhinav Diwan, Yuqin Wang, Michael S. Diamond, Sean P. J. Whelan, and Siyuan Ding
  
  PNAS December 15, 2020 117 (50) 32105-32113; first published November 25, 2020. https://doi.org/10.1073/pnas.2012197117
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Neuroscience
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  Inverse correlation between fatty acid transport protein 4 and vision in Leber congenital amaurosis associated with RPE65 mutation
  Songhua Li, William C. Gordon, Nicolas G. Bazan, and Minghao Jin
  
  PNAS December 15, 2020 117 (50) 32114-32123; first published November 30, 2020. https://doi.org/10.1073/pnas.2012623117
  
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  A goal-driven modular neural network predicts parietofrontal neural dynamics during grasping
  Jonathan A. Michaels, Stefan Schaffelhofer, Andres Agudelo-Toro, and Hansjörg Scherberger
  
  PNAS December 15, 2020 117 (50) 32124-32135; first published November 30, 2020. https://doi.org/10.1073/pnas.2005087117
  
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  Seasonal plasticity in the adult somatosensory cortex
  
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  Saikat Ray, Miao Li, Stefan Paul Koch, Susanne Mueller, Philipp Boehm-Sturm, Hong Wang, Michael Brecht, and Robert Konrad Naumann
  
  PNAS December 15, 2020 117 (50) 32136-32144; first published November 30, 2020. https://doi.org/10.1073/pnas.1922888117
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  The NLRP3 inflammasome inhibitor OLT1177 rescues cognitive impairment in a mouse model of Alzheimer’s disease
  Niklas Lonnemann, Shirin Hosseini, Carlo Marchetti, Damaris B. Skouras, Davide Stefanoni, Angelo D’Alessandro, Charles A. Dinarello, and Martin Korte
  
  PNAS December 15, 2020 117 (50) 32145-32154; first published November 30, 2020. https://doi.org/10.1073/pnas.2009680117
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  Targeting presynaptic H3 heteroreceptor in nucleus accumbens to improve anxiety and obsessive-compulsive-like behaviors
  Xiao-Yang Zhang, Shi-Yu Peng, Li-Ping Shen, Qian-Xing Zhuang, Bin Li, Shu-Tao Xie, Qian-Xiao Li, Ming-Run Shi, Tian-Yu Ma, Qipeng Zhang, Jian-Jun Wang, and Jing-Ning Zhu
  
  PNAS December 15, 2020 117 (50) 32155-32164; first published November 30, 2020. https://doi.org/10.1073/pnas.2008456117
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Psychological and Cognitive Sciences
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  Valuation of peers’ safe choices is associated with substance-naïveté in adolescents
  Dongil Chung, Mark A. Orloff, Nina Lauharatanahirun, Pearl H. Chiu, and Brooks King-Casas
  
  PNAS December 15, 2020 117 (50) 31729-31737; first published November 30, 2020. https://doi.org/10.1073/pnas.1919111117
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  Visual motion assists in social cognition
  Arvid Guterstam and Michael S. A. Graziano
  
  PNAS December 15, 2020 117 (50) 32165-32168; first published November 30, 2020. https://doi.org/10.1073/pnas.2021325117
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  Time-dependent discrimination advantages for harmonic sounds suggest efficient coding for memory
  Malinda J. McPherson and Josh H. McDermott
  
  PNAS December 15, 2020 117 (50) 32169-32180; first published December 1, 2020. https://doi.org/10.1073/pnas.2008956117
  
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