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November 10, 2020; vol. 117 no. 45

This Week in PNAS

This week's research highlights

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In This Issue
PNAS November 10, 2020 117 (45) 27747-27748; https://doi.org/10.1073/iti4520117
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Opinion

Leading scientists discuss current issues

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Opinion: A risk–benefit framework for human research during the COVID-19 pandemic
Front Matter
Julie C. Lumeng, Tabbye M. Chavous, Anna S. Lok, Srijan Sen, Nicholas S. Wigginton, and Rebecca M. Cunningham

PNAS November 10, 2020 117 (45) 27749-27753; first published October 21, 2020. https://doi.org/10.1073/pnas.2020507117
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Core Concepts

A brief introduction to emerging topics in science

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Core Concept: The pandemic is prompting widespread use—and misuse—of real-world data
Front Matter
Elie Dolgin

PNAS November 10, 2020 117 (45) 27754-27758; first published October 21, 2020. https://doi.org/10.1073/pnas.2020930117
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Retrospective

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Zena Werb (1945–2020): Mourning the loss of a tissue microenvironment icon
Valerie M. Weaver and Mina J. Bissell

PNAS November 10, 2020 117 (45) 27759-27760; first published October 29, 2020. https://doi.org/10.1073/pnas.2020162117
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Commentaries

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p31^comet and TRIP13 recycle Rev7 to regulate DNA repair
Kevin D. Corbett

PNAS November 10, 2020 117 (45) 27761-27763; first published October 29, 2020. https://doi.org/10.1073/pnas.2020103117

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p31^comet promotes homologous recombination by inactivating REV7 through the TRIP13 ATPase
- Oct 13, 2020
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The microbiome requires a genetically susceptible host to induce central nervous system autoimmunity
Laura M. Cox and Howard L. Weiner

PNAS November 10, 2020 117 (45) 27764-27766; first published October 29, 2020. https://doi.org/10.1073/pnas.2020106117

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Interactions between host genetics and gut microbiota determine susceptibility to CNS autoimmunity
- Oct 19, 2020
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Perspective

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The pandemic exposes human nature: 10 evolutionary insights
Benjamin M. Seitz, Athena Aktipis, David M. Buss, Joe Alcock, Paul Bloom, Michele Gelfand, Sam Harris, Debra Lieberman, Barbara N. Horowitz, Steven Pinker, David Sloan Wilson, and Martie G. Haselton

PNAS November 10, 2020 117 (45) 27767-27776; first published October 22, 2020. https://doi.org/10.1073/pnas.2009787117
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Open Access
It is unclear how important CRISPR-Cas systems are for protecting natural populations of bacteria against infections by mobile genetic elements
Edze R. Westra and Bruce R. Levin

PNAS November 10, 2020 117 (45) 27777-27785; first published October 29, 2020. https://doi.org/10.1073/pnas.1915966117
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Letters

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Crystalline water in gypsum is unavailable for cyanobacteria in laboratory experiments and in natural desert endolithic habitats
Jacek Wierzchos, Octavio Artieda, Carmen Ascaso, Fernando Nieto García, Petr Vítek, Armando Azua-Bustos, and Alberto G. Fairén

PNAS November 10, 2020 117 (45) 27786-27787; first published October 22, 2020. https://doi.org/10.1073/pnas.2013134117

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Reply to Wierzchos et al.: Microorganism-induced gypsum to anhydrite phase transformation
Wei Huang, Emine Ertekin, Taifeng Wang, Luz Cruz, Micah Dailey, Jocelyne DiRuggiero, and David Kisailus

PNAS November 10, 2020 117 (45) 27788-27790; first published October 22, 2020. https://doi.org/10.1073/pnas.2018184117

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Mechanism of water extraction from gypsum rock by desert colonizing microorganisms
- May 04, 2020
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RCP8.5 is a problematic scenario for near-term emissions
Zeke Hausfather and Glen P. Peters

PNAS November 10, 2020 117 (45) 27791-27792; first published October 20, 2020. https://doi.org/10.1073/pnas.2017124117

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Reply to Hausfather and Peters: RCP8.5 is neither problematic nor misleading
Christopher R. Schwalm, Spencer Glendon, and Philip B. Duffy

PNAS November 10, 2020 117 (45) 27793-27794; first published October 20, 2020. https://doi.org/10.1073/pnas.2018008117

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RCP8.5 tracks cumulative CO₂ emissions
- Aug 03, 2020
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Physical Sciences

Applied Mathematics
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  Origin of exponential growth in nonlinear reaction networks
  Wei-Hsiang Lin, Edo Kussell, Lai-Sang Young, and Christine Jacobs-Wagner
  
  PNAS November 10, 2020 117 (45) 27795-27804; first published October 22, 2020. https://doi.org/10.1073/pnas.2013061117
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  Electoral College bias and the 2020 presidential election
  Robert S. Erikson, Karl Sigman, and Linan Yao
  
  PNAS November 10, 2020 117 (45) 27940-27944; first published October 26, 2020. https://doi.org/10.1073/pnas.2013581117
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  High-amplitude cofluctuations in cortical activity drive functional connectivity
  Farnaz Zamani Esfahlani, Youngheun Jo, Joshua Faskowitz, Lisa Byrge, Daniel P. Kennedy, Olaf Sporns, and Richard F. Betzel
  
  PNAS November 10, 2020 117 (45) 28393-28401; first published October 22, 2020. https://doi.org/10.1073/pnas.2005531117
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Applied Physical Sciences
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  A symmetry-derived mechanism for atomic resolution imaging
  
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  Matus Krajnak and Joanne Etheridge
  
  PNAS November 10, 2020 117 (45) 27805-27810; first published October 22, 2020. https://doi.org/10.1073/pnas.2006975117
  
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Biophysics and Computational Biology
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  Abnormal morphology biases hematocrit distribution in tumor vasculature and contributes to heterogeneity in tissue oxygenation
  Miguel O. Bernabeu, Jakub Köry, James A. Grogan, Bostjan Markelc, Albert Beardo, Mayeul d’Avezac, Romain Enjalbert, Jakob Kaeppler, Nicholas Daly, James Hetherington, Timm Krüger, Philip K. Maini, Joe M. Pitt-Francis, Ruth J. Muschel, Tomás Alarcón, and Helen M. Byrne
  
  PNAS November 10, 2020 117 (45) 27811-27819; first published October 27, 2020. https://doi.org/10.1073/pnas.2007770117
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  Laser spectroscopic technique for direct identification of a single virus I: FASTER CARS
  Volker Deckert, Tanja Deckert-Gaudig, Dana Cialla-May, Jürgen Popp, Roland Zell, Stefanie Deinhard-Emmer, Alexei V. Sokolov, Zhenhuan Yi, and Marlan O. Scully
  
  PNAS November 10, 2020 117 (45) 27820-27824; first published October 22, 2020. https://doi.org/10.1073/pnas.2013169117
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  A far-red cyanobacteriochrome lineage specific for verdins
  Marcus V. Moreno, Nathan C. Rockwell, Manuel Mora, Andrew J. Fisher, and J. Clark Lagarias
  
  PNAS November 10, 2020 117 (45) 27962-27970; first published October 26, 2020. https://doi.org/10.1073/pnas.2016047117
  
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  The human CRY1 tail controls circadian timing by regulating its association with CLOCK:BMAL1
  Gian Carlo G. Parico, Ivette Perez, Jennifer L. Fribourgh, Britney N. Hernandez, Hsiau-Wei Lee, and Carrie L. Partch
  
  PNAS November 10, 2020 117 (45) 27971-27979; first published October 26, 2020. https://doi.org/10.1073/pnas.1920653117
  
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  Wake-sleep cycles are severely disrupted by diseases affecting cytoplasmic homeostasis
  Stephen Beesley, Dae Wook Kim, Matthew D’Alessandro, Yuanhu Jin, Kwangjun Lee, Hyunjeong Joo, Yang Young, Robert J. Tomko Jr, John Faulkner, Joshua Gamsby, Jae Kyoung Kim, and Choogon Lee
  
  PNAS November 10, 2020 117 (45) 28402-28411; first published October 26, 2020. https://doi.org/10.1073/pnas.2003524117
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  Improving the taxonomy of fossil pollen using convolutional neural networks and superresolution microscopy
  
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  Ingrid C. Romero, Shu Kong, Charless C. Fowlkes, Carlos Jaramillo, Michael A. Urban, Francisca Oboh-Ikuenobe, Carlos D’Apolito, and Surangi W. Punyasena
  
  PNAS November 10, 2020 117 (45) 28496-28505; first published October 23, 2020. https://doi.org/10.1073/pnas.2007324117
  
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  Deep learning in deep time
  - Nov 09, 2020
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Chemistry
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  Insights into the composition of ancient Egyptian red and black inks on papyri achieved by synchrotron-based microanalyses
  Thomas Christiansen, Marine Cotte, Wout de Nolf, Elouan Mouro, Juan Reyes-Herrera, Steven de Meyer, Frederik Vanmeert, Nati Salvadó, Victor Gonzalez, Poul Erik Lindelof, Kell Mortensen, Kim Ryholt, Koen Janssens, and Sine Larsen
  
  PNAS November 10, 2020 117 (45) 27825-27835; first published October 26, 2020. https://doi.org/10.1073/pnas.2004534117
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  Nearly free surface silanols are the critical molecular moieties that initiate the toxicity of silica particles
  Cristina Pavan, Rosangela Santalucia, Riccardo Leinardi, Marco Fabbiani, Yousof Yakoub, Francine Uwambayinema, Piero Ugliengo, Maura Tomatis, Gianmario Martra, Francesco Turci, Dominique Lison, and Bice Fubini
  
  PNAS November 10, 2020 117 (45) 27836-27846; first published October 23, 2020. https://doi.org/10.1073/pnas.2008006117
  
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  Are nearly free silanols a unifying structural determinant of silica particle toxicity?
  - Nov 13, 2020
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  A high-performance potassium metal battery using safe ionic liquid electrolyte
  
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  Hao Sun, Peng Liang, Guanzhou Zhu, Wei Hsuan Hung, Yuan-Yao Li, Hung-Chun Tai, Cheng-Liang Huang, Jiachen Li, Yongtao Meng, Michael Angell, Chang-An Wang, and Hongjie Dai
  
  PNAS November 10, 2020 117 (45) 27847-27853; first published October 26, 2020. https://doi.org/10.1073/pnas.2012716117
  
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  Anionic nanoparticle-induced perturbation to phospholipid membranes affects ion channel function
  Isabel U. Foreman-Ortiz, Dongyue Liang, Elizabeth D. Laudadio, Jorge D. Calderin, Meng Wu, Puspam Keshri, Xianzhi Zhang, Michael P. Schwartz, Robert J. Hamers, Vincent M. Rotello, Catherine J. Murphy, Qiang Cui, and Joel A. Pedersen
  
  PNAS November 10, 2020 117 (45) 27854-27861; first published October 26, 2020. https://doi.org/10.1073/pnas.2004736117
  
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Computer Sciences
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  A spiking neural program for sensorimotor control during foraging in flying insects
  Hannes Rapp and Martin Paul Nawrot
  
  PNAS November 10, 2020 117 (45) 28412-28421; first published October 29, 2020. https://doi.org/10.1073/pnas.2009821117
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Earth, Atmospheric, and Planetary Sciences
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  Anthropogenic Asian aerosols provide Fe to the North Pacific Ocean
  Paulina Pinedo-González, Nicholas J. Hawco, Randelle M. Bundy, E. Virginia Armbrust, Michael J. Follows, B. B. Cael, Angelicque E. White, Sara Ferrón, David M. Karl, and Seth G. John
  
  PNAS November 10, 2020 117 (45) 27862-27868; first published October 22, 2020. https://doi.org/10.1073/pnas.2010315117
  
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  Evidence for massive emission of methane from a deep‐water gas field during the Pliocene
  Martino Foschi, Joseph A. Cartwright, Christopher W. MacMinn, and Giuseppe Etiope
  
  PNAS November 10, 2020 117 (45) 27869-27876; first published October 26, 2020. https://doi.org/10.1073/pnas.2001904117
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  Causes and consequences of asymmetric lateral plume flow during South Atlantic rifting
  
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  Jason P. Morgan, Jorge M. Taramón, Mario Araujo, Jörg Hasenclever, and Marta Perez-Gussinye
  
  PNAS November 10, 2020 117 (45) 27877-27883; first published October 26, 2020. https://doi.org/10.1073/pnas.2012246117
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  The critical role of cloud–infrared radiation feedback in tropical cyclone development
  James H. Ruppert Jr, Allison A. Wing, Xiaodong Tang, and Erika L. Duran
  
  PNAS November 10, 2020 117 (45) 27884-27892; first published October 26, 2020. https://doi.org/10.1073/pnas.2013584117
  
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  The niobium and tantalum concentration in the mantle constrains the composition of Earth’s primordial magma ocean
  Dongyang Huang, James Badro, and Julien Siebert
  
  PNAS November 10, 2020 117 (45) 27893-27898; first published October 26, 2020. https://doi.org/10.1073/pnas.2007982117
  
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  Experimental evidence for silica-enriched Earth’s lower mantle with ferrous iron dominant bridgmanite
  Izumi Mashino, Motohiko Murakami, Nobuyoshi Miyajima, and Sylvain Petitgirard
  
  PNAS November 10, 2020 117 (45) 27899-27905; first published October 22, 2020. https://doi.org/10.1073/pnas.1917096117
  
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Engineering
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  Soft, skin-interfaced microfluidic systems with integrated immunoassays, fluorometric sensors, and impedance measurement capabilities
  Sungbong Kim, Boram Lee, Jonathan T. Reeder, Seon Hee Seo, Sung-Uk Lee, Aurélie Hourlier-Fargette, Joonchul Shin, Yurina Sekine, Hyoyoung Jeong, Yong Suk Oh, Alexander J. Aranyosi, Stephen P. Lee, Jeffrey B. Model, Geumbee Lee, Min-Ho Seo, Sung Soo Kwak, Seongbin Jo, Gyungmin Park, Sunghyun Han, Inkyu Park, Hyo-Il Jung, Roozbeh Ghaffari, Jahyun Koo, Paul V. Braun, and John A. Rogers
  
  PNAS November 10, 2020 117 (45) 27906-27915; first published October 26, 2020. https://doi.org/10.1073/pnas.2012700117
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  Reconfigurable multifunctional ferrofluid droplet robots
  
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  Xinjian Fan, Xiaoguang Dong, Alp C. Karacakol, Hui Xie, and Metin Sitti
  
  PNAS November 10, 2020 117 (45) 27916-27926; first published October 26, 2020. https://doi.org/10.1073/pnas.2016388117
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  Insect pectinate antennae maximize odor capture efficiency at intermediate flight speeds
  Mourad Jaffar-Bandjee, Thomas Steinmann, Gijs Krijnen, and Jérôme Casas
  
  PNAS November 10, 2020 117 (45) 28126-28133; first published October 29, 2020. https://doi.org/10.1073/pnas.2007871117
  
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Physics
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  Two-step crystallization and solid–solid transitions in binary colloidal mixtures
  
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  Huang Fang, Michael F. Hagan, and W. Benjamin Rogers
  
  PNAS November 10, 2020 117 (45) 27927-27933; first published October 29, 2020. https://doi.org/10.1073/pnas.2008561117
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Biological Sciences

Applied Biological Sciences
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  Elucidating aromatic acid tolerance at low pH in Saccharomyces cerevisiae using adaptive laboratory evolution
  Rui Pereira, Elsayed T. Mohamed, Mohammad S. Radi, Markus J. Herrgård, Adam M. Feist, Jens Nielsen, and Yun Chen
  
  PNAS November 10, 2020 117 (45) 27954-27961; first published October 26, 2020. https://doi.org/10.1073/pnas.2013044117
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Biochemistry
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  A far-red cyanobacteriochrome lineage specific for verdins
  Marcus V. Moreno, Nathan C. Rockwell, Manuel Mora, Andrew J. Fisher, and J. Clark Lagarias
  
  PNAS November 10, 2020 117 (45) 27962-27970; first published October 26, 2020. https://doi.org/10.1073/pnas.2016047117
  
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  The human CRY1 tail controls circadian timing by regulating its association with CLOCK:BMAL1
  Gian Carlo G. Parico, Ivette Perez, Jennifer L. Fribourgh, Britney N. Hernandez, Hsiau-Wei Lee, and Carrie L. Partch
  
  PNAS November 10, 2020 117 (45) 27971-27979; first published October 26, 2020. https://doi.org/10.1073/pnas.1920653117
  
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  Mcl-1 and Bok transmembrane domains: Unexpected players in the modulation of apoptosis
  Estefanía Lucendo, Mónica Sancho, Fabio Lolicato, Matti Javanainen, Waldemar Kulig, Diego Leiva, Gerard Duart, Vicente Andreu-Fernández, Ismael Mingarro, and Mar Orzáez
  
  PNAS November 10, 2020 117 (45) 27980-27988; first published October 22, 2020. https://doi.org/10.1073/pnas.2008885117
  
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  Reversible autoinhibitory regulation of Escherichia coli metallopeptidase BepA for selective β-barrel protein degradation
  Yasushi Daimon, Shin-ichiro Narita, Ryoji Miyazaki, Yohei Hizukuri, Hiroyuki Mori, Yoshiki Tanaka, Tomoya Tsukazaki, and Yoshinori Akiyama
  
  PNAS November 10, 2020 117 (45) 27989-27996; first published October 22, 2020. https://doi.org/10.1073/pnas.2010301117
  
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  Amyloid formation of fish β-parvalbumin involves primary nucleation triggered by disulfide-bridged protein dimers
  Tony E. R. Werner, David Bernson, Elin K. Esbjörner, Sandra Rocha, and Pernilla Wittung-Stafshede
  
  PNAS November 10, 2020 117 (45) 27997-28004; first published October 22, 2020. https://doi.org/10.1073/pnas.2015503117
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  Multistep substrate binding and engagement by the AAA+ ClpXP protease
  Reuben A. Saunders, Benjamin M. Stinson, Tania A. Baker, and Robert T. Sauer
  
  PNAS November 10, 2020 117 (45) 28005-28013; first published October 26, 2020. https://doi.org/10.1073/pnas.2010804117
  
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Biophysics and Computational Biology
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  Origin of exponential growth in nonlinear reaction networks
  Wei-Hsiang Lin, Edo Kussell, Lai-Sang Young, and Christine Jacobs-Wagner
  
  PNAS November 10, 2020 117 (45) 27795-27804; first published October 22, 2020. https://doi.org/10.1073/pnas.2013061117
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  Multistep substrate binding and engagement by the AAA+ ClpXP protease
  Reuben A. Saunders, Benjamin M. Stinson, Tania A. Baker, and Robert T. Sauer
  
  PNAS November 10, 2020 117 (45) 28005-28013; first published October 26, 2020. https://doi.org/10.1073/pnas.2010804117
  
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  Visualization of the HIV-1 Env glycan shield across scales
  Zachary T. Berndsen, Srirupa Chakraborty, Xiaoning Wang, Christopher A. Cottrell, Jonathan L. Torres, Jolene K. Diedrich, Cesar A. López, John R. Yates III, Marit J. van Gils, James C. Paulson, Sandrasegaram Gnanakaran, and Andrew B. Ward
  
  PNAS November 10, 2020 117 (45) 28014-28025; first published October 22, 2020. https://doi.org/10.1073/pnas.2000260117
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  SurA is a cryptically grooved chaperone that expands unfolded outer membrane proteins
  Dagan C. Marx, Ashlee M. Plummer, Anneliese M. Faustino, Taylor Devlin, Michaela A. Roskopf, Mathis J. Leblanc, Henry J. Lessen, Barbara T. Amann, Patrick J. Fleming, Susan Krueger, Stephen D. Fried, and Karen G. Fleming
  
  PNAS November 10, 2020 117 (45) 28026-28035; first published October 22, 2020. https://doi.org/10.1073/pnas.2008175117
  
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  The role of Ca²⁺ and protein scaffolding in the formation of nature’s water oxidizing complex
  Anton P. Avramov, Hong J. Hwang, and Robert L. Burnap
  
  PNAS November 10, 2020 117 (45) 28036-28045; first published October 26, 2020. https://doi.org/10.1073/pnas.2011315117
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  Engineered ACE2 receptor traps potently neutralize SARS-CoV-2
  Anum Glasgow, Jeff Glasgow, Daniel Limonta, Paige Solomon, Irene Lui, Yang Zhang, Matthew A. Nix, Nicholas J. Rettko, Shoshana Zha, Rachel Yamin, Kevin Kao, Oren S. Rosenberg, Jeffrey V. Ravetch, Arun P. Wiita, Kevin K. Leung, Shion A. Lim, Xin X. Zhou, Tom C. Hobman, Tanja Kortemme, and James A. Wells
  
  PNAS November 10, 2020 117 (45) 28046-28055; first published October 22, 2020. https://doi.org/10.1073/pnas.2016093117
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Cell Biology
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  PtdIns(3,4,5)P₃-dependent Rac exchanger 1 (P-Rex1) promotes mammary tumor initiation and metastasis
  Nuthasuda Srijakotre, Heng-Jia Liu, Max Nobis, Joey Man, Hon Yan Kelvin Yip, Antonella Papa, Helen E. Abud, Kurt I. Anderson, Heidi C. E. Welch, Tony Tiganis, Paul Timpson, Catriona A. McLean, Lisa M. Ooms, and Christina A. Mitchell
  
  PNAS November 10, 2020 117 (45) 28056-28067; first published October 23, 2020. https://doi.org/10.1073/pnas.2006445117
  
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  Targeted CRISPR screening identifies PRMT5 as synthetic lethality combinatorial target with gemcitabine in pancreatic cancer cells
  Xiaolong Wei, Jiekun Yang, Sara J. Adair, Harun Ozturk, Cem Kuscu, Kyung Yong Lee, William J. Kane, Patrick E. O’Hara, Denis Liu, Yusuf Mert Demirlenk, Alaa Hamdi Habieb, Ebru Yilmaz, Anindya Dutta, Todd W. Bauer, and Mazhar Adli
  
  PNAS November 10, 2020 117 (45) 28068-28079; first published October 23, 2020. https://doi.org/10.1073/pnas.2009899117
  
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  Identification of a degradation signal at the carboxy terminus of SREBP2: A new role for this domain in cholesterol homeostasis
  Daniel L. Kober, Shimeng Xu, Shili Li, Bilkish Bajaj, Guosheng Liang, Daniel M. Rosenbaum, and Arun Radhakrishnan
  
  PNAS November 10, 2020 117 (45) 28080-28091; first published October 26, 2020. https://doi.org/10.1073/pnas.2018578117
  
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  RNA-binding protein DDX3 mediates posttranscriptional regulation of androgen receptor: A mechanism of castration resistance
  Jordan E. Vellky, Sean T. McSweeney, Emily A. Ricke, and William A. Ricke
  
  PNAS November 10, 2020 117 (45) 28092-28101; first published October 26, 2020. https://doi.org/10.1073/pnas.2008479117
  
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  Myelination of peripheral nerves is controlled by PI4KB through regulation of Schwann cell Golgi function
  
  From the Cover
  
  Takashi Baba, Alejandro Alvarez-Prats, Yeun Ju Kim, Daniel Abebe, Steve Wilson, Zane Aldworth, Mark A. Stopfer, John Heuser, and Tamas Balla
  
  PNAS November 10, 2020 117 (45) 28102-28113; first published October 26, 2020. https://doi.org/10.1073/pnas.2007432117
  
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  A Golgi-associated lipid kinase controls peripheral nerve myelination
  - Nov 13, 2020
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  USP7 regulates ALS-associated proteotoxicity and quality control through the NEDD4L–SMAD pathway
  Tao Zhang, Goran Periz, Yu-Ning Lu, and Jiou Wang
  
  PNAS November 10, 2020 117 (45) 28114-28125; first published October 26, 2020. https://doi.org/10.1073/pnas.2014349117
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Ecology
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  Insect pectinate antennae maximize odor capture efficiency at intermediate flight speeds
  Mourad Jaffar-Bandjee, Thomas Steinmann, Gijs Krijnen, and Jérôme Casas
  
  PNAS November 10, 2020 117 (45) 28126-28133; first published October 29, 2020. https://doi.org/10.1073/pnas.2007871117
  
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  A global network of marine protected areas for food
  
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  Reniel B. Cabral, Darcy Bradley, Juan Mayorga, Whitney Goodell, Alan M. Friedlander, Enric Sala, Christopher Costello, and Steven D. Gaines
  
  PNAS November 10, 2020 117 (45) 28134-28139; first published October 26, 2020. https://doi.org/10.1073/pnas.2000174117
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  Land-use intensity alters networks between biodiversity, ecosystem functions, and services
  María R. Felipe-Lucia, Santiago Soliveres, Caterina Penone, Markus Fischer, Christian Ammer, Steffen Boch, Runa S. Boeddinghaus, Michael Bonkowski, François Buscot, Anna Maria Fiore-Donno, Kevin Frank, Kezia Goldmann, Martin M. Gossner, Norbert Hölzel, Malte Jochum, Ellen Kandeler, Valentin H. Klaus, Till Kleinebecker, Sophia Leimer, Peter Manning, Yvonne Oelmann, Hugo Saiz, Peter Schall, Michael Schloter, Ingo Schöning, Marion Schrumpf, Emily F. Solly, Barbara Stempfhuber, Wolfgang W. Weisser, Wolfgang Wilcke, Tesfaye Wubet, and Eric Allan
  
  PNAS November 10, 2020 117 (45) 28140-28149; first published October 22, 2020. https://doi.org/10.1073/pnas.2016210117
  
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  Ancient genomes reveal tropical bovid species in the Tibetan Plateau contributed to the prevalence of hunting game until the late Neolithic
  Ningbo Chen, Lele Ren, Linyao Du, Jiawen Hou, Victoria E. Mullin, Duo Wu, Xueye Zhao, Chunmei Li, Jiahui Huang, Xuebin Qi, Marco Rosario Capodiferro, Alessandro Achilli, Chuzhao Lei, Fahu Chen, Bing Su, Guanghui Dong, and Xiaoming Zhang
  
  PNAS November 10, 2020 117 (45) 28150-28159; first published October 19, 2020. https://doi.org/10.1073/pnas.2011696117
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  Climate drives the geography of marine consumption by changing predator communities
  
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  Matthew A. Whalen, Ross D. B. Whippo, John J. Stachowicz, Paul H. York, Erin Aiello, Teresa Alcoverro, Andrew H. Altieri, Lisandro Benedetti-Cecchi, Camilla Bertolini, Midoli Bresch, Fabio Bulleri, Paul E. Carnell, Stéphanie Cimon, Rod M. Connolly, Mathieu Cusson, Meredith S. Diskin, Elrika D’Souza, Augusto A. V. Flores, F. Joel Fodrie, Aaron W. E. Galloway, Leo C. Gaskins, Olivia J. Graham, Torrance C. Hanley, Christopher J. Henderson, Clara M. Hereu, Margot Hessing-Lewis, Kevin A. Hovel, Brent B. Hughes, A. Randall Hughes, Kristin M. Hultgren, Holger Jänes, Dean S. Janiak, Lane N. Johnston, Pablo Jorgensen, Brendan P. Kelaher, Claudia Kruschel, Brendan S. Lanham, Kun-Seop Lee, Jonathan S. Lefcheck, Enrique Lozano-Álvarez, Peter I. Macreadie, Zachary L. Monteith, Nessa E. O’Connor, Andrew D. Olds, Jennifer K. O’Leary, Christopher J. Patrick, Oscar Pino, Alistair G. B. Poore, Michael A. Rasheed, Wendel W. Raymond, Katrin Reiss, O. Kennedy Rhoades, Max T. Robinson, Paige G. Ross, Francesca Rossi, Thomas A. Schlacher, Janina Seemann, Brian R. Silliman, Delbert L. Smee, Martin Thiel, Richard K. F. Unsworth, Brigitta I. van Tussenbroek, Adriana Vergés, Mallarie E. Yeager, Bree K. Yednock, Shelby L. Ziegler, and J. Emmett Duffy
  
  PNAS November 10, 2020 117 (45) 28160-28166; first published October 26, 2020. https://doi.org/10.1073/pnas.2005255117
  
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  Modular genetic control of social status in a cichlid fish
  Beau A. Alward, Vibhav A. Laud, Christopher J. Skalnik, Ryan A. York, Scott A. Juntti, and Russell D. Fernald
  
  PNAS November 10, 2020 117 (45) 28167-28174; first published October 26, 2020. https://doi.org/10.1073/pnas.2008925117
  
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Environmental Sciences
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  Outsized nutrient contributions from small tributaries to a Great Lake
  Robert J. Mooney, Emily H. Stanley, William C. Rosenthal, Peter C. Esselman, Anthony D. Kendall, and Peter B. McIntyre
  
  PNAS November 10, 2020 117 (45) 28175-28182; first published October 26, 2020. https://doi.org/10.1073/pnas.2001376117
  
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  Floristic evidence for alternative biome states in tropical Africa
  J. C. Aleman, A. Fayolle, C. Favier, A. C. Staver, K. G. Dexter, C. M. Ryan, A. F. Azihou, D. Bauman, M. te Beest, E. N. Chidumayo, J. A. Comiskey, J. P. G. M. Cromsigt, H. Dessard, J.-L. Doucet, M. Finckh, J.-F. Gillet, S. Gourlet-Fleury, G. P. Hempson, R. M. Holdo, B. Kirunda, F. N. Kouame, G. Mahy, F. Maiato P. Gonçalves, I. McNicol, P. Nieto Quintano, A. J. Plumptre, R. C. Pritchard, R. Revermann, C. B. Schmitt, A. M. Swemmer, H. Talila, E. Woollen, and M. D. Swaine
  
  PNAS November 10, 2020 117 (45) 28183-28190; first published October 27, 2020. https://doi.org/10.1073/pnas.2011515117
  
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Genetics
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  Genome-wide mapping of spontaneous genetic alterations in diploid yeast cells
  Yang Sui, Lei Qi, Jian-Kun Wu, Xue-Ping Wen, Xing-Xing Tang, Zhong-Jun Ma, Xue-Chang Wu, Ke Zhang, Robert J. Kokoska, Dao-Qiong Zheng, and Thomas D. Petes
  
  PNAS November 10, 2020 117 (45) 28191-28200; first published October 26, 2020. https://doi.org/10.1073/pnas.2018633117
  
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  Hundreds of thousands of cell generations reveal a treasure chest of genome alterations
  - Nov 16, 2020
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  Comprehensive characterization of amino acid positions in protein structures reveals molecular effect of missense variants
  Sumaiya Iqbal, Eduardo Pérez-Palma, Jakob B. Jespersen, Patrick May, David Hoksza, Henrike O. Heyne, Shehab S. Ahmed, Zaara T. Rifat, M. Sohel Rahman, Kasper Lage, Aarno Palotie, Jeffrey R. Cottrell, Florence F. Wagner, Mark J. Daly, Arthur J. Campbell, and Dennis Lal
  
  PNAS November 10, 2020 117 (45) 28201-28211; first published October 26, 2020. https://doi.org/10.1073/pnas.2002660117
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  A mosaic analysis system with Cre or Tomato expression in the mouse
  Qun Wang, Yen-Yu Lin, Baojun Zhang, Jianxuan Wu, Sumedha Roy, Jeremy J. Ratiu, Yanping Xu, Meifang Dai, Laura P. Hale, Yue Xiong, Qi-Jing Li, and Yuan Zhuang
  
  PNAS November 10, 2020 117 (45) 28212-28220; first published October 26, 2020. https://doi.org/10.1073/pnas.2014308117
  
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  A MASCOT for mosaic analysis
  - Nov 16, 2020
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  Characterization of systemic genomic instability in budding yeast
  Nadia M. V. Sampaio, V. P. Ajith, Ruth A. Watson, Lydia R. Heasley, Parijat Chakraborty, Aline Rodrigues-Prause, Ewa P. Malc, Piotr A. Mieczkowski, Koodali T. Nishant, and Juan Lucas Argueso
  
  PNAS November 10, 2020 117 (45) 28221-28231; first published October 26, 2020. https://doi.org/10.1073/pnas.2010303117
  
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Immunology and Inflammation
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  Nearly free surface silanols are the critical molecular moieties that initiate the toxicity of silica particles
  Cristina Pavan, Rosangela Santalucia, Riccardo Leinardi, Marco Fabbiani, Yousof Yakoub, Francine Uwambayinema, Piero Ugliengo, Maura Tomatis, Gianmario Martra, Francesco Turci, Dominique Lison, and Bice Fubini
  
  PNAS November 10, 2020 117 (45) 27836-27846; first published October 23, 2020. https://doi.org/10.1073/pnas.2008006117
  
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  Are nearly free silanols a unifying structural determinant of silica particle toxicity?
  - Nov 13, 2020
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  HLA tapasin independence: broader peptide repertoire and HIV control
  Arman A. Bashirova, Mathias Viard, Vivek Naranbhai, Alba Grifoni, Wilfredo Garcia-Beltran, Marjan Akdag, Yuko Yuki, Xiaojiang Gao, Colm O’hUigin, Malini Raghavan, Steven Wolinsky, Jay H. Bream, Priya Duggal, Jeremy Martinson, Nelson L. Michael, Gregory D. Kirk, Susan P. Buchbinder, David Haas, James J. Goedert, Steven G. Deeks, Jacques Fellay, Bruce Walker, Philip Goulder, Peter Cresswell, Tim Elliott, Alessandro Sette, Jonathan Carlson, and Mary Carrington
  
  PNAS November 10, 2020 117 (45) 28232-28238; first published October 23, 2020. https://doi.org/10.1073/pnas.2013554117
  
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  HLA polymorphism and tapasin independence influence outcomes of HIV and dengue virus infection
  - Nov 25, 2020
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  KLHL22 maintains PD-1 homeostasis and prevents excessive T cell suppression
  Xiao Albert Zhou, Jiadong Zhou, Long Zhao, Guihui Yu, Jun Zhan, Chanyi Shi, Ruoshi Yuan, Yan Wang, Changfeng Chen, Wenjia Zhang, Donghao Xu, Yingjiang Ye, Weibin Wang, Zhanlong Shen, Wei Wang, and Jiadong Wang
  
  PNAS November 10, 2020 117 (45) 28239-28250; first published October 27, 2020. https://doi.org/10.1073/pnas.2004570117
  
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  Phosphatidylinositol-4-kinase IIα licenses phagosomes for TLR4 signaling and MHC-II presentation in dendritic cells
  
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  Cynthia López-Haber, Roni Levin-Konigsberg, Yueyao Zhu, Jing Bi-Karchin, Tamas Balla, Sergio Grinstein, Michael S. Marks, and Adriana R. Mantegazza
  
  PNAS November 10, 2020 117 (45) 28251-28262; first published October 27, 2020. https://doi.org/10.1073/pnas.2001948117
  
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  Stimulation of soluble guanylate cyclase exerts antiinflammatory actions in the liver through a VASP/NF-κB/NLRP3 inflammasome circuit
  Roger Flores-Costa, Marta Duran-Güell, Mireia Casulleras, Cristina López-Vicario, José Alcaraz-Quiles, Alba Diaz, Juan J. Lozano, Esther Titos, Katherine Hall, Renee Sarno, Jaime L. Masferrer, and Joan Clària
  
  PNAS November 10, 2020 117 (45) 28263-28274; first published October 26, 2020. https://doi.org/10.1073/pnas.2000466117
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Medical Sciences
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  Abnormal morphology biases hematocrit distribution in tumor vasculature and contributes to heterogeneity in tissue oxygenation
  Miguel O. Bernabeu, Jakub Köry, James A. Grogan, Bostjan Markelc, Albert Beardo, Mayeul d’Avezac, Romain Enjalbert, Jakob Kaeppler, Nicholas Daly, James Hetherington, Timm Krüger, Philip K. Maini, Joe M. Pitt-Francis, Ruth J. Muschel, Tomás Alarcón, and Helen M. Byrne
  
  PNAS November 10, 2020 117 (45) 27811-27819; first published October 27, 2020. https://doi.org/10.1073/pnas.2007770117
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  GPR56/ADGRG1 is a platelet collagen-responsive GPCR and hemostatic sensor of shear force
  
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  Jennifer Yeung, Reheman Adili, Emily N. Stringham, Rong Luo, Alexander Vizurraga, Luciana K. Rosselli-Murai, Hannah M. Stoveken, Maiya Yu, Xianhua Piao, Michael Holinstat, and Gregory G. Tall
  
  PNAS November 10, 2020 117 (45) 28275-28286; first published October 23, 2020. https://doi.org/10.1073/pnas.2008921117
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  FOXM1 drives HPV+ HNSCC sensitivity to WEE1 inhibition
  
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  Ahmed Diab, Hakan Gem, Jherek Swanger, Hee Yeon Kim, Kaleb Smith, Grace Zou, Sharat Raju, Michael Kao, Matthew Fitzgibbon, Keith R. Loeb, Cristina P. Rodriguez, Eduardo Méndez, Denise A. Galloway, Julia M. Sidorova, and Bruce E. Clurman
  
  PNAS November 10, 2020 117 (45) 28287-28296; first published October 22, 2020. https://doi.org/10.1073/pnas.2013921117
  
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  An allosteric peptide inhibitor of HIF-1α regulates hypoxia-induced retinal neovascularization
  Ayumi Usui-Ouchi, Edith Aguilar, Salome Murinello, Mitchell Prins, Marin L. Gantner, Peter E. Wright, Rebecca B. Berlow, and Martin Friedlander
  
  PNAS November 10, 2020 117 (45) 28297-28306; first published October 26, 2020. https://doi.org/10.1073/pnas.2017234117
  
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  The adaptor protein APPL2 controls glucose-stimulated insulin secretion via F-actin remodeling in pancreatic β-cells
  
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  Baile Wang, Huige Lin, Xiaomu Li, Wenqi Lu, Jae Bum Kim, Aimin Xu, and Kenneth K. Y. Cheng
  
  PNAS November 10, 2020 117 (45) 28307-28315; first published October 29, 2020. https://doi.org/10.1073/pnas.2016997117
  
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  Harnessing ⁶⁴Cu/⁶⁷Cu for a theranostic approach to pretargeted radioimmunotherapy
  Outi Keinänen, Kimberly Fung, James M. Brennan, Nicholas Zia, Matt Harris, Ellen van Dam, Colin Biggin, Amos Hedt, Jon Stoner, Paul S. Donnelly, Jason S. Lewis, and Brian M. Zeglis
  
  PNAS November 10, 2020 117 (45) 28316-28327; first published October 26, 2020. https://doi.org/10.1073/pnas.2009960117
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Microbiology
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  A genomic and historical synthesis of plague in 18th century Eurasia
  Meriam Guellil, Oliver Kersten, Amine Namouchi, Stefania Luciani, Isolina Marota, Caroline A. Arcini, Elisabeth Iregren, Robert A. Lindemann, Gunnar Warfvinge, Lela Bakanidze, Lia Bitadze, Mauro Rubini, Paola Zaio, Monica Zaio, Damiano Neri, N. C. Stenseth, and Barbara Bramanti
  
  PNAS November 10, 2020 117 (45) 28328-28335; first published October 26, 2020. https://doi.org/10.1073/pnas.2009677117
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  Transcriptional and proteomic insights into the host response in fatal COVID-19 cases
  
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  Meng Wu, Yaobing Chen, Han Xia, Changli Wang, Chin Yee Tan, Xunhui Cai, Yufeng Liu, Fenghu Ji, Peng Xiong, Ran Liu, Yuanlin Guan, Yaqi Duan, Dong Kuang, Sanpeng Xu, Hanghang Cai, Qin Xia, Dehua Yang, Ming-Wei Wang, Isaac M. Chiu, Chao Cheng, Philip P. Ahern, Liang Liu, Guoping Wang, Neeraj K. Surana, Tian Xia, and Dennis L. Kasper
  
  PNAS November 10, 2020 117 (45) 28336-28343; first published October 20, 2020. https://doi.org/10.1073/pnas.2018030117
  
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  In fatal COVID-19, the immune response can control the virus but kill the patient
  - Nov 11, 2020
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  SARS-CoV-2 Orf6 hijacks Nup98 to block STAT nuclear import and antagonize interferon signaling
  
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  Lisa Miorin, Thomas Kehrer, Maria Teresa Sanchez-Aparicio, Ke Zhang, Phillip Cohen, Roosheel S. Patel, Anastasija Cupic, Tadashi Makio, Menghan Mei, Elena Moreno, Oded Danziger, Kris M. White, Raveen Rathnasinghe, Melissa Uccellini, Shengyan Gao, Teresa Aydillo, Ignacio Mena, Xin Yin, Laura Martin-Sancho, Nevan J. Krogan, Sumit K. Chanda, Michael Schotsaert, Richard W. Wozniak, Yi Ren, Brad R. Rosenberg, Beatriz M. A. Fontoura, and Adolfo García-Sastre
  
  PNAS November 10, 2020 117 (45) 28344-28354; first published October 23, 2020. https://doi.org/10.1073/pnas.2016650117
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  Insights into bacterial cell division from a structure of EnvC bound to the FtsX periplasmic domain
  
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  Jonathan Cook, Tyler C. Baverstock, Martin B. L. McAndrew, Phillip J. Stansfeld, David I. Roper, and Allister Crow
  
  PNAS November 10, 2020 117 (45) 28355-28365; first published October 23, 2020. https://doi.org/10.1073/pnas.2017134117
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  The polar Ras-like GTPase MglA activates type IV pilus via SgmX to enable twitching motility in Myxococcus xanthus
  
  Video
  
  Romain Mercier, Sarah Bautista, Maëlle Delannoy, Margaux Gibert, Annick Guiseppi, Julien Herrou, Emilia M. F. Mauriello, and Tâm Mignot
  
  PNAS November 10, 2020 117 (45) 28366-28373; first published October 22, 2020. https://doi.org/10.1073/pnas.2002783117
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  The shrimp nephrocomplex serves as a major portal of pathogen entry and is involved in the molting process
  Gaëtan M. A. De Gryse, Thuong Van Khuong, Benedicte Descamps, Wim Van Den Broeck, Christian Vanhove, Pieter Cornillie, Patrick Sorgeloos, Peter Bossier, and Hans J. Nauwynck
  
  PNAS November 10, 2020 117 (45) 28374-28383; first published October 23, 2020. https://doi.org/10.1073/pnas.2013518117
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  A CRISPR-Cas9 screen identifies mitochondrial translation as an essential process in latent KSHV infection of human endothelial cells
  Daniel L. Holmes, Daniel T. Vogt, and Michael Lagunoff
  
  PNAS November 10, 2020 117 (45) 28384-28392; first published October 29, 2020. https://doi.org/10.1073/pnas.2011645117
  
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Neuroscience
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  High-amplitude cofluctuations in cortical activity drive functional connectivity
  Farnaz Zamani Esfahlani, Youngheun Jo, Joshua Faskowitz, Lisa Byrge, Daniel P. Kennedy, Olaf Sporns, and Richard F. Betzel
  
  PNAS November 10, 2020 117 (45) 28393-28401; first published October 22, 2020. https://doi.org/10.1073/pnas.2005531117
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  Wake-sleep cycles are severely disrupted by diseases affecting cytoplasmic homeostasis
  
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  Stephen Beesley, Dae Wook Kim, Matthew D’Alessandro, Yuanhu Jin, Kwangjun Lee, Hyunjeong Joo, Yang Young, Robert J. Tomko Jr, John Faulkner, Joshua Gamsby, Jae Kyoung Kim, and Choogon Lee
  
  PNAS November 10, 2020 117 (45) 28402-28411; first published October 26, 2020. https://doi.org/10.1073/pnas.2003524117
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  A spiking neural program for sensorimotor control during foraging in flying insects
  Hannes Rapp and Martin Paul Nawrot
  
  PNAS November 10, 2020 117 (45) 28412-28421; first published October 29, 2020. https://doi.org/10.1073/pnas.2009821117
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  Evolution of regulatory signatures in primate cortical neurons at cell-type resolution
  Alexey Kozlenkov, Marit W. Vermunt, Pasha Apontes, Junhao Li, Ke Hao, Chet C. Sherwood, Patrick R. Hof, John J. Ely, Michael Wegner, Eran A. Mukamel, Menno P. Creyghton, Eugene V. Koonin, and Stella Dracheva
  
  PNAS November 10, 2020 117 (45) 28422-28432; first published October 27, 2020. https://doi.org/10.1073/pnas.2011884117
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  Evidence for an effector-independent action system from people born without hands
  
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  Yuqi Liu, Gilles Vannuscorps, Alfonso Caramazza, and Ella Striem-Amit
  
  PNAS November 10, 2020 117 (45) 28433-28441; first published October 26, 2020. https://doi.org/10.1073/pnas.2017789117
  
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  Transforming abstract plans into concrete actions
  - Nov 11, 2020
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  Simple transformations capture auditory input to cortex
  Monzilur Rahman, Ben D. B. Willmore, Andrew J. King, and Nicol S. Harper
  
  PNAS November 10, 2020 117 (45) 28442-28451; first published October 23, 2020. https://doi.org/10.1073/pnas.1922033117
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  Differential functional connectivity underlying asymmetric reward-related activity in human and nonhuman primates
  Alizée Lopez-Persem, Léa Roumazeilles, Davide Folloni, Kévin Marche, Elsa F. Fouragnan, Nima Khalighinejad, Matthew F. S. Rushworth, and Jérôme Sallet
  
  PNAS November 10, 2020 117 (45) 28452-28462; first published October 29, 2020. https://doi.org/10.1073/pnas.2000759117
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  Time cells in the human hippocampus and entorhinal cortex support episodic memory
  Gray Umbach, Pranish Kantak, Joshua Jacobs, Michael Kahana, Brad E. Pfeiffer, Michael Sperling, and Bradley Lega
  
  PNAS November 10, 2020 117 (45) 28463-28474; first published October 27, 2020. https://doi.org/10.1073/pnas.2013250117
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  Echolocating bats detect but misperceive a multidimensional incongruent acoustic stimulus
  Sasha Danilovich, Gal Shalev, Arjan Boonman, Aya Goldshtein, and Yossi Yovel
  
  PNAS November 10, 2020 117 (45) 28475-28484; first published October 26, 2020. https://doi.org/10.1073/pnas.2005009117
  
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Physiology
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  The odorant receptor OR2W3 on airway smooth muscle evokes bronchodilation via a cooperative chemosensory tradeoff between TMEM16A and CFTR
  Jessie Huang, Hong Lam, Cynthia Koziol-White, Nathachit Limjunyawong, Donghwa Kim, Nicholas Kim, Nikhil Karmacharya, Premraj Rajkumar, Danielle Firer, Nicholas M. Dalesio, Joseph Jude, Richard C. Kurten, Jennifer L. Pluznick, Deepak A. Deshpande, Raymond B. Penn, Stephen B. Liggett, Reynold A. Panettieri Jr, Xinzhong Dong, and Steven S. An
  
  PNAS November 10, 2020 117 (45) 28485-28495; first published October 23, 2020. https://doi.org/10.1073/pnas.2003111117
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Plant Biology
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  Improving the taxonomy of fossil pollen using convolutional neural networks and superresolution microscopy
  
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  Ingrid C. Romero, Shu Kong, Charless C. Fowlkes, Carlos Jaramillo, Michael A. Urban, Francisca Oboh-Ikuenobe, Carlos D’Apolito, and Surangi W. Punyasena
  
  PNAS November 10, 2020 117 (45) 28496-28505; first published October 23, 2020. https://doi.org/10.1073/pnas.2007324117
  
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  Deep learning in deep time
  - Nov 09, 2020
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Population Biology
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  Fine-scale spatial clustering of measles nonvaccination that increases outbreak potential is obscured by aggregated reporting data
  Nina B. Masters, Marisa C. Eisenberg, Paul L. Delamater, Matthew Kay, Matthew L. Boulton, and Jon Zelner
  
  PNAS November 10, 2020 117 (45) 28506-28514; first published October 26, 2020. https://doi.org/10.1073/pnas.2011529117
  
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Sustainability Science
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  Land-use intensity alters networks between biodiversity, ecosystem functions, and services
  María R. Felipe-Lucia, Santiago Soliveres, Caterina Penone, Markus Fischer, Christian Ammer, Steffen Boch, Runa S. Boeddinghaus, Michael Bonkowski, François Buscot, Anna Maria Fiore-Donno, Kevin Frank, Kezia Goldmann, Martin M. Gossner, Norbert Hölzel, Malte Jochum, Ellen Kandeler, Valentin H. Klaus, Till Kleinebecker, Sophia Leimer, Peter Manning, Yvonne Oelmann, Hugo Saiz, Peter Schall, Michael Schloter, Ingo Schöning, Marion Schrumpf, Emily F. Solly, Barbara Stempfhuber, Wolfgang W. Weisser, Wolfgang Wilcke, Tesfaye Wubet, and Eric Allan
  
  PNAS November 10, 2020 117 (45) 28140-28149; first published October 22, 2020. https://doi.org/10.1073/pnas.2016210117
  
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  Improving rural health care reduces illegal logging and conserves carbon in a tropical forest
  Isabel J. Jones, Andrew J. MacDonald, Skylar R. Hopkins, Andrea J. Lund, Zac Yung-Chun Liu, Nurul Ihsan Fawzi, Mahardika Putra Purba, Katie Fankhauser, Andrew J. Chamberlin, Monica Nirmala, Arthur G. Blundell, Ashley Emerson, Jonathan Jennings, Lynne Gaffikin, Michele Barry, David Lopez-Carr, Kinari Webb, Giulio A. De Leo, and Susanne H. Sokolow
  
  PNAS November 10, 2020 117 (45) 28515-28524; first published October 26, 2020. https://doi.org/10.1073/pnas.2009240117
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Corrections

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Correction for Wu et al., Isolation of exosomes from whole blood by integrating acoustics and microfluidicss
PNAS November 10, 2020 117 (45) 28525; first published October 19, 2020. https://doi.org/10.1073/pnas.2020183117
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Correction for Rao et al., Inositol pyrophosphates promote tumor growth and metastasis by antagonizing liver kinase B1
PNAS November 10, 2020 117 (45) 28526-28527; first published October 26, 2020. https://doi.org/10.1073/pnas.2019638117
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Correction for Bao et al., BACE1 SUMOylation increases its stability and escalates the protease activity in Alzheimer’s disease
PNAS November 10, 2020 117 (45) 28528-28530; first published October 26, 2020. https://doi.org/10.1073/pnas.2019837117
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Correction for Bos et al., Phytophthora infestans effector AVR3a is essential for virulence and manipulates plant immunity by stabilizing host E3 ligase CMPG1
PNAS November 10, 2020 117 (45) 28531-28533; first published October 26, 2020. https://doi.org/10.1073/pnas.2019643117
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